Soluble ST2 Testing: A Promising Biomarker in the Management of Heart Failure
نویسندگان
چکیده
ST2 is a member of the interleukin-1 receptor family biomarker and circulating soluble ST2 concentrations are believed to reflect cardiovascular stress and fibrosis. Recent studies have demonstrated soluble ST2 to be a strong predictor of cardiovascular outcomes in both chronic and acute heart failure. It is a new biomarker that meets all required criteria for a useful biomarker. Of note, it adds information to natriuretic peptides (NPs) and some studies have shown it is even superior in terms of risk stratification. Since the introduction of NPs, this has been the most promising biomarker in the field of heart failure and might be particularly useful as therapy guide.
منابع مشابه
Prognostic Value of Soluble ST2 (sST2) Serum Levels in Infants and Children with Heart Failure Complicating Congenital Heart Disease
Background Heart failure (HF) in infants and children with congenital heart disease (CHD) is a crucial complication with different outcomes. Many biomarkers are used as prognostic indicators. Soluble ST2 (sST2) is one of these markers studied in adults with HF. We aimed to study the prognostic value of sST2 in CHD children with HF. Materials and Methods In current case-control study, thirty-six...
متن کاملIdentification of serum soluble ST2 receptor as a novel heart failure biomarker.
BACKGROUND Using genomic technology, we previously identified an interleukin-1 receptor family member, ST2, as a gene markedly induced by mechanical strain in cardiac myocytes. The soluble receptor form of ST2 is secreted and detectable in human serum. This study tested the hypothesis that soluble ST2 levels in the serum of patients with severe chronic heart failure are increased in patients wi...
متن کاملSoluble ST2: A Novel Prognostic Biomarker of Heart Failure.
Previous studies have demonstrated the role of ST2 in predicting hospitalization and mortality in heart failure, independent of natriuretic peptides and other clinical variables. 9-17 In 2011, the U.S. Food and Drug Administration (FDA) delared the Presage ST2 Assay (Critical Diagnostics, San Diego, California, USA), which is typically used in conjunction with clinical evaluation as an aid in a...
متن کاملSoluble ST2 in ambulatory patients with heart failure: Association with functional capacity and long-term outcomes.
BACKGROUND ST2 is involved in cardioprotective signaling in the myocardium and has been identified as a potentially promising biomarker in heart failure (HF). We evaluated ST2 levels and their association with functional capacity and long-term clinical outcomes in a cohort of ambulatory patients with HF enrolled in the Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Trainin...
متن کاملGrowth-Differentiation Factor-15 as Additional Prognostic Biomarkers in Heart Failure
Heart Failure (HF) remains to be a leading factor of cardiovascular morbidity and mortality. Although risk stratification of HF is promising prediction care, there are several controversies regarding choosing more optimal combinations of biomarkers and method (single versus serial measurements) of biomarker use in routine clinical practice. Growth differentiation factor-15 (GDF-15) is considere...
متن کامل